Takepron OD Dosage/Direction for Use

TAKEPRON is available as a capsule and as an OD tablet. Both are available in 15 mg and 30 mg strengths. Directions for use specific to the route and available methods of administration for each of these dosage forms is presented as follows. TAKEPRON should be taken before eating.
TAKEPRON capsule and OD tablet should not be crushed or chewed. In the clinical trials, antacids were used concomitantly with. (See Table 17.)

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Patients should be instructed that if a dose is missed, it should be taken as soon as possible. However, if the next scheduled dose is due, the patient should not take the missed dose, and should be instructed to take the next dose on time. Patients should be instructed not to take two doses at one time to make up for a missed dose.
Special Populations: Renal impairment patients and geriatric patients do not require dosage adjustment. However, consider dose adjustment in patients with severe liver impairment (see Use in Children, Use in Elderly and Renal Impairment under Precautions).
Important Administration Information: Administration Options: TAKEPRON OD Tablets - Orally Disintegrating Tablets: TAKEPRON OD should not be broken or cut.
TAKEPRON OD should not be chewed.
Place the tablet on the tongue and allow it to disintegrate, with or without water, until the particles can be swallowed.
The tablet typically disintegrates in less than one minute.
Alternatively, for children or other patients who have difficulty swallowing tablets, TAKEPRON OD can be delivered in two different ways.
TAKEPRON OD Tablets - Oral Syringe: For administration via oral syringe, TAKEPRON OD can be administered as follows: Place a 15 mg tablet in oral syringe and draw up 4 mL of water, or place a 30 mg tablet in oral syringe and draw up 10 mL of water.
Shake gently to allow for a quick dispersal.
After the tablet has dispersed, administer the contents within 15 minutes.
Refill the syringe with approximately 2 mL (5 mL for the 30 mg tablet) of water, shake gently, and administer any remaining contents.
TAKEPRON OD Tablets - Nasogastric Tube (≥8 French) Administration: For administration via a nasogastric tube, TAKEPRON OD Tablets can be administered as follows: Place a 15 mg tablet in a syringe and draw up 4 mL of water, or place a 30 mg tablet in a syringe and draw up 10 mL of water.
Shake gently to allow for a quick dispersal.
After the tablet has dispersed, inject through the nasogastric tube into the stomach within 15 minutes.
Refill the syringe with approximately 5 mL of water, shake gently, and flush the nasogastric tube.